Identifying the cells breaching self-tolerance in autoimmunity

Benson, Robert A., Patakas, Agapitos, Conigliaro, Paola, Rush, Catherine M., Garside, Paul, McInnes, Iain B., and Brewer, James M. (2010) Identifying the cells breaching self-tolerance in autoimmunity. Journal of Immunology, 184 (11). pp. 6378-6385.

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Abstract

Activation of auto-reactive T cells by activated dendritic cells (DCs) presenting self-Ag is widely assumed to be the precipitating event in the development of autoimmune disease. However, despite such widely held preconceptions, supporting data are scarce and subjective, particularly in experimental arthropathy. We have adapted a novel murine model of breach of self-tolerance allowing evaluation of the contribution of endogenous DCs to the development of autoimmune responses and disease. For the first time, we reveal the critical role played by conventional DCs, and the timing and location of this process. We further demonstrate the importance of this finding by clinically relevant, therapeutic manipulation of conventional DC function, resulting in decreased autoimmune phenotype and disease severity.

Item ID: 15736
Item Type: Article (Refereed Research - C1)
ISSN: 1550-6606
Date Deposited: 18 Mar 2011 01:27
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110704 Cellular Immunology @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110703 Autoimmunity @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 100%
Citation Count from Web of Science Web of Science 9
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