Antibiosis of Burkholderia ubonensis against Burkholderia pseudomallei, the causative agent for melioidosis

Marshall, Kristy, Shakya, Sabina, Greenhill, Andrew R., Padilla, Gabriel, Baker, Anthony, and Warner, Jeffrey M. (2010) Antibiosis of Burkholderia ubonensis against Burkholderia pseudomallei, the causative agent for melioidosis. Southeast Asian Journal of Tropical Medicine and Public Health, 41 (4). pp. 904-912.

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Abstract

Melioidosis, caused by Burkholderia pseudomallei, is an enigmatic infectious disease that afflicts individuals in many tropical and developing regions. Treatment is hampered by the organism's innate antibiotic resistance and the disease's non-pathognomic presentation. Recently, added attention has been given to this organism due to its classification as a potential biowarfare agent. Therefore, methods of preventing acquisition of infection are needed. We investigated antagonism between Burkholderia spp and B. pseudomallei derived from the same ecological niche in a melioidosis endemic region in Papua New Guinea. Isolates of environmentally derived non-pseudomallei Burkholderia spp (n=16) were screened for antibiosis against 27 B. pseudomallei isolates. Three isolates subsequently identified as B. ubonensis produced specific antagonistic activity against all B. pseudomallei isolates tested. The antagonistic compound in a cell-free state was obtained from a representative producing strain, with subsequent biological characterization revealing a pepsin sensitive peptide moiety consistent with a bacteriocin-like compound. To our knowledge, this is the first report of antagonistic activity demonstrated by near-neighbor Burkholderia against B. pseudomallei . This antagonism may be important in the micro-ecology of B. pseudomallei, and could also have application in the biocontrol of this pathogen.

Item ID: 15009
Item Type: Article (Refereed Research - C1)
Keywords: Burkholderia pseudomallei, B. ubonensis, antibiosis, melioidosis
ISSN: 0125-1562
Date Deposited: 16 Dec 2010 01:47
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110303 Clinical Microbiology @ 50%
06 BIOLOGICAL SCIENCES > 0605 Microbiology > 060505 Mycology @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 50%
92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920406 Food Safety @ 20%
92 HEALTH > 9205 Specific Population Health (excl. Indigenous Health) > 920506 Rural Health @ 30%
Citation Count from Web of Science Web of Science 6
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