Particle production in monodisperse emulsions

Dombrowski, Richard D., Wagner, Norman J., He, Yinghe, and Litster, James D. (2005) Particle production in monodisperse emulsions. In: Proceedings of 33rd Australasian Chemical Engineering Conference. From: Chemeca 2005, 25-28 September 2005, Brisbane, QLD, Australia.

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Abstract

Crystallization from surfactant-free, monodisperse emulsions was investigated as a method for controlling the crystal size distribution (CSD) of lactose crystals. Microfluidic T-junctions were used to produce water-in-oil emulsion drops with diameters in the range of 165 to 300 micron with a coefficient of variation of drop sizes less than 3%. Lactose was crystallized in drops formed from the microfluidic T-junction using a plug flow crystallizer. The fraction of drops containing single crystals first increases as the initial lactose supersaturation is increased then decreases due to a higher nucleation rate at high supersaturation. The narrowest CSD is obtained when the fraction of drops containing single crystals is highest. The CV of the size of crystals produced by emulsion crystallization was as low as 14%, compared with 40% for seeded bulk crystallization.

Item ID: 14792
Item Type: Conference Item (Refereed Research Paper - E1)
Keywords: crystal size; crystal size distribution; emulsion crystallization; monodisperse emulsions
ISBN: 978-1-86499-832-0
Date Deposited: 26 Nov 2010 05:00
FoR Codes: 09 ENGINEERING > 0904 Chemical Engineering > 090499 Chemical Engineering not elsewhere classified @ 40%
07 AGRICULTURAL AND VETERINARY SCIENCES > 0707 Veterinary Sciences > 070799 Veterinary Sciences not elsewhere classified @ 30%
11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified @ 30%
SEO Codes: 86 MANUFACTURING > 8608 Human Pharmaceutical Products > 860801 Human Biological Preventatives (e.g. Vaccines) @ 51%
86 MANUFACTURING > 8609 Veterinary Pharmaceutical Products > 860901 Veterinary Biological Preventatives (e.g. Vaccines) @ 49%
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