Application of laminar jet break-up to the preparation of monodisperse microparticulate drug delivery systems

Rahman, Mohammad M. , He, Yinghe, and Davies, Nigel M. (2005) Application of laminar jet break-up to the preparation of monodisperse microparticulate drug delivery systems. In: Proceedings of 33rd Australasian Chemical Engineering Conference. From: Chemeca 2005, 25-28 September 2005, Brisbane, QLD, Australia.

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Abstract

Studies were conducted to investigate the feasibility of using natural laminar jet break-up for the preparation of oil-in-water dispersions which could be used as templates for the fabrication of mono disperse biodegradable poly(ester) microparticles of controlled and predictable size suitable for drug delivery. Poly(ε-caprolactone) was used as a model poly(ester) and dissolved in dichloromethane. The organic polymer solution was jetted into a continuous aqueous phase containing poly(vinyl alcohol) as a surfactant using a syringe pump. The system was subsequently stirred to facilitate solvent removal leading to polymer precipitation and microparticle formation. Resulting microparticles were characterized by optical microscopy and low angle laser light scattering. The effect of orifice diameter, flow rate (particularly within the laminar jet region), and polymer and surfactant concentrations on the size and polydispersity of the microparticles was investigated. Particles having a narrow size distributions were produced throughout the laminar jet region under the conditions studied. Particle size and polydispersity was observed to decrease as the flow rate within the laminar region increased approaching the maximum jet length. However, this effect was less pronounced with smaller diameter orifices. Particle size of the microspheres as expected was dependent on both the orifice size and polymer concentration. A linear relationship was noted between orifice diameter and microsphere size suggesting that particles of predictable size can be prepared using selected orifice diameters. No relationship however was observed between polymer concentration and particle size and this interaction requires further investigation. These studies demonstrate that microparticles with a narrow size distribution can be prepared from oil-in-water dispersions produced by laminar jet break-up. Further, the size of the resulting microparticles, a critical parameter in drug delivery can be readily controlled and manipulated by varying the orifice size. Poly(ester) microparticles having a size between 50 and 300 micrometers were thus readily prepared by this method which could be developed as a method for the preparation of microparticles of predictable, narrow and controlled size by manipulating the conditions used.

Item ID: 14789
Item Type: Conference Item (Refereed Research Paper - E1)
Keywords: drug delivery; laminar jet breakup; microencapsulation; particle size
ISBN: 978-1-86499-832-0
Date Deposited: 26 Nov 2010 05:40
FoR Codes: 09 ENGINEERING > 0904 Chemical Engineering > 090499 Chemical Engineering not elsewhere classified @ 40%
07 AGRICULTURAL AND VETERINARY SCIENCES > 0707 Veterinary Sciences > 070799 Veterinary Sciences not elsewhere classified @ 30%
11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified @ 30%
SEO Codes: 86 MANUFACTURING > 8608 Human Pharmaceutical Products > 860801 Human Biological Preventatives (e.g. Vaccines) @ 51%
86 MANUFACTURING > 8609 Veterinary Pharmaceutical Products > 860901 Veterinary Biological Preventatives (e.g. Vaccines) @ 49%
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