Molecular structural characteristics of estrogen receptor modulators as determinants of estrogen receptor selectivity
Agatonovic-Kustrin, S., and Turner, J.V. (2008) Molecular structural characteristics of estrogen receptor modulators as determinants of estrogen receptor selectivity. Mini-Reviews in Medicinal Chemistry, 8 (9). pp. 943-951.
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Abstract
This review will discuss the structural determinants and requirements necessary for estrogen receptors alpha and beta selectivity and ligand-receptor binding affinity. In addition, strategies likely to result in the development of a pharmacophore model that account for the differences in estrogenic effects between different ligands will be discussed.
| Item ID: | 14167 |
|---|---|
| Item Type: | Article (Research - C1) |
| ISSN: | 1875-5607 |
| Keywords: | computer aided drug design; molecular modeling; structure-activity relationships; hormones; QSAR; phytoestrogens |
| Date Deposited: | 10 Mar 2011 00:48 |
| FoR Codes: | 11 MEDICAL AND HEALTH SCIENCES > 1199 Other Medical and Health Sciences > 119999 Medical and Health Sciences not elsewhere classified @ 100% |
| SEO Codes: | 92 HEALTH > 9299 Other Health > 929999 Health not elsewhere classified @ 100% |
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