Maillard reaction products in food as pro-inflammatory and pro-arteriosclerotic factors of degenerative diseases

Webster, J., Wilke, M., Stahl, P., Kientsch-Engel, R., and Münch, G. (2005) Maillard reaction products in food as pro-inflammatory and pro-arteriosclerotic factors of degenerative diseases. Zeitschrift fuer Gerontologie und Geriatrie, 38 (5). pp. 347-353.

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Abstract

Heating of food induces the formation of Maillard reaction products (MRPs) caused by the reaction of reducing sugars with proteins or amino acids. Analogous reactions occur in the human body, eventually forming "Advanced Glycation Endproducts" (AGEs). AGEs accumulate in aging tissues accelerating degenerative-inflammatory and proliferative processes. MRPs present in food can also directly cause inflammatory processes in the intestines and, once absorbed, would support and reinforce any inflammatory and degenerative process occurring in the body. The contribution of AGEs (and additional MRPs) in the development of diabetic complications as well as nephropathy, neuropathy, micro- and macroangiopathies is now well established. Which of the MRPs or AGEs in particular induce these cellular processes is currently unknown. Thus the exact knowledge of the chemical structures of the MRPs could help to minimize the formation of "harmful MRPs" that occur due to heating in food processing. Because MRPs play a decisive role in the successful marketing of edibles due to their characteristics as flavor components, it is important to increase the amount of innocuous and palatable MRPs, and minimize signal active pro-inflammatory MRPs by the use of defined preparation methods. It is practicable to use low-priced immunological methods for the quantitative determination of specific MRPs or AGEs. In the medical area, the knowledge of the signal active MRP/AGE structures provides the opportunity to measure their concentrations in body fluids and tissues and thus determine their influence on inflammatory and age-related degenerative processes (e. g., late diabetic complications, arteriosclerosis, degeneration of neurons). From a clinical perspective, the application of RAGE antagonists after an appropriate chemical diagnosis could be effective in supporting the treatment of affected patient groups, especially older diabetic and dialysis patients.

Item ID: 14103
Item Type: Article (Refereed Research - C1)
Keywords: advanced glycation end products
Additional Information:

German title: Maillardprodukte aus Lebensmitteln als pro-entzündliche und pro-arteriosklerotische faktoren bei degeneratriven erkrankungen

ISSN: 1435-1269
Date Deposited: 01 Dec 2010 00:32
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110999 Neurosciences not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920111 Nervous System and Disorders @ 100%
Citation Count from Web of Science Web of Science 6
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