Application of linear mixed effects models to the evaluation of dissolution profiles

Adams, E., Coomans, D., Smeyers-Verbeke, J., and Massart, D.L. (2001) Application of linear mixed effects models to the evaluation of dissolution profiles. International Journal of Pharmaceutics, 226 (1-2). pp. 107-125.

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Abstract

The performance of linear mixed effects models for the comparison of dissolution profiles is examined. This type of model is frequently used by statisticians, but is rather unknown to people that work in dissolution laboratories. Hence, an extensive theoretical part was introduced to make the methodology more accessible. Firstly, repeated measures ANOVA is discussed, followed by the 'real' linear mixed effects models. The theory is applied to two types of dissolution data: one corresponding to an immediate and another to a slow release formulation. We tried to use as much as possible the standard settings of the statistical software (S-plus). Suggestions are given to solve problems encountered during model fitting. It was found that the statistical limits are much more discriminative than the similarity factor.

Item ID: 13240
Item Type: Article (Refereed Research - C1)
Keywords: disssolution; linear mixed models; longitudinal data; pharmaceutical statistics
ISSN: 1873-3476
Date Deposited: 31 Jul 2012 06:27
FoR Codes: 01 MATHEMATICAL SCIENCES > 0104 Statistics > 010401 Applied Statistics @ 100%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970101 Expanding Knowledge in the Mathematical Sciences @ 100%
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