Associations between the tumor necrosis factor alpha gene (-308G→A) and event-related potential indices of attention and mental rotation
Beste, C., Heil, M., Domschke, K., Baune, B.T., and Konrad, C. (2010) Associations between the tumor necrosis factor alpha gene (-308G→A) and event-related potential indices of attention and mental rotation. Neuroscience, 170 (3). pp. 742-748.
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The tumor necrosis factor alpha (TNF-α) is a cytokine that exerts neuroprotective and neurodegenerative effects. While some research suggests enhancing effects of the TNF-α gene (TNF-α -308G→A) on cognitive function, further research is needed to clarify the association between the TNF-α gene and specific areas of cognitive performance including their neurophysiological correlates. In this study we examine association of the TNF-α -308G→A single nucleotide polymorphism (rs1800629) with attention and mental rotation performance in an event-related potential (ERP) study in healthy participants (n=67). The results show that carriers of the -308 A allele display elevated attentional processes (i.e. a stronger N1) as compared to the GG genotype group. Mental rotation performance varied across genotypes when demands on mental rotation were high. Here, carriers of the -308 A allele performed better than the GG genotype group. This is paralleled by the neurophysiological data showing genotype-dependent variations in parietal positivities only under the condition of high demands on mental rotation. The finding of enhanced attentional and mental rotation performance in A allele carriers supports recent findings that the A allele of this single nucleotide polymorphism (SNP) enhances cognitive performance on a general measure of cognitive processing speed.
|Item Type:||Article (Refereed Research - C1)|
|Keywords:||attention, mental rotation, event-related potentials (ERPs), tumor necrosis factor alpha (TNF-), cytokines, imaging genetics|
|Date Deposited:||01 Oct 2010 02:12|
|FoR Codes:||11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110999 Neurosciences not elsewhere classified @ 100%|
|SEO Codes:||92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920410 Mental Health @ 100%|
|Citation Count from Web of Science||