A comparison of antibiotic regimens in the treatment of acute melioidosis in a mouse model

Ulett, Glen C., Hirst, Robert, Bowden, Bruce, Powell, Kellie, and Norton, Robert (2003) A comparison of antibiotic regimens in the treatment of acute melioidosis in a mouse model. Journal of Antimicrobial Chemotherapy, 51 (1). pp. 77-81.

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Melioidosis is caused by the Gram-negative bacillus Burkholderia pseudomallei. Most clinical reports of disease are from south-east Asia and northern Australia. The organism is intrinsically resistant to most commonly available antibiotics. Standard therapy includes ceftazidime either alone or in combination with co-trimoxazole. The clinical advantage in adding cotrimoxazole has never been determined; nor has the activity of newer, fourth-generation cephalosporins, such as cefepime, been studied in the treatment of this condition. BALB/c mice have been shown to represent an animal model of melioidosis. This animal model was used in this study to compare the efficacy of ceftazidime and cefepime alone or with co-trimoxazole, in the therapy of melioidosis. Antibiotic levels in the mice were determined by HPLC, and dosing was modified to keep plasma antibiotic levels at or above the MIC for the organism–antibiotic combination for a significant part of a 12 h period. Bacterial load, as determined by splenic counts, showed that ceftazidime in combination with co-trimoxazole was the most effective therapeutic option. The animal model described in this study can be used as a preliminary evaluation of therapeutic options for melioidosis.

Item ID: 1064
Item Type: Article (Refereed Research - C1)
Keywords: meliodosis, Pseudomonas pseudomallei
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Copyright © 2003 Oxford University Press. The published version of this article can be accessed via Oxford Journals. Use hypertext links above.

ISSN: 1460-2091
Date Deposited: 06 Nov 2006
FoR Codes: 07 AGRICULTURAL AND VETERINARY SCIENCES > 0707 Veterinary Sciences > 070707 Veterinary Microbiology (excl Virology) @ 51%
07 AGRICULTURAL AND VETERINARY SCIENCES > 0707 Veterinary Sciences > 070799 Veterinary Sciences not elsewhere classified @ 49%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920412 Preventive Medicine @ 100%
Citation Count from Web of Science Web of Science 10
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