Genes mediating environment interactions in type 1 diabetes

Biros, Erik, Jordan, Margaret A., and Baxter, Alan G. (2005) Genes mediating environment interactions in type 1 diabetes. Review of Diabetic Studies, 2 (4). pp. 192-207.

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Abstract

The relative risk of type 1 (autoimmune) diabetes mellitus for a sibling of an affected patient is fifteen times that of the general population, indicating a strong genetic contribution to the disease. Yet, the incidence of diabetes in most Western communities has doubled every fifteen years since the Second World War - a rate of increase that can only possibly be explained by a major etiological effect of environment. Here, the authors provide a selective review of risk factors identified to date. Recent reports of linkage of type 1 diabetes to genes encoding pathogen pattern recognition molecules, such as toll-like receptors, are discussed, providing a testable hypothesis regarding a mechanism by which genetic and environmental influences on disease progress are integrated.

Item ID: 10344
Item Type: Article (Refereed Research - C1)
Keywords: type 1 diabetes; genes; environment
ISSN: 1614-0575
Date Deposited: 30 Apr 2010 03:08
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110703 Autoimmunity @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920104 Diabetes @ 100%
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