Genes mediating environment interactions in type 1 diabetes
Biros, Erik, Jordan, Margaret A., and Baxter, Alan G. (2005) Genes mediating environment interactions in type 1 diabetes. Review of Diabetic Studies, 2 (4). pp. 192-207.
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The relative risk of type 1 (autoimmune) diabetes mellitus for a sibling of an affected patient is fifteen times that of the general population, indicating a strong genetic contribution to the disease. Yet, the incidence of diabetes in most Western communities has doubled every fifteen years since the Second World War - a rate of increase that can only possibly be explained by a major etiological effect of environment. Here, the authors provide a selective review of risk factors identified to date. Recent reports of linkage of type 1 diabetes to genes encoding pathogen pattern recognition molecules, such as toll-like receptors, are discussed, providing a testable hypothesis regarding a mechanism by which genetic and environmental influences on disease progress are integrated.
|Item Type:||Article (Refereed Research - C1)|
|Keywords:||type 1 diabetes; genes; environment|
|Date Deposited:||30 Apr 2010 03:08|
|FoR Codes:||11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110703 Autoimmunity @ 100%|
|SEO Codes:||92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920104 Diabetes @ 100%|