Exposure to Burkholderia pseudomallei induces cell-mediated immunity in healthy individuals

Govan, B., and Ketheesan, N. (2004) Exposure to Burkholderia pseudomallei induces cell-mediated immunity in healthy individuals. Clinical Microbiology and Infection, 10 (6). pp. 585-587.

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Abstract

Melioidosis is an emerging tropical infection caused by the intracellular bacterium Burkholderia pseudomallei, and is associated with high mortality rates. Previous studies investigating the prevalence of melioidosis have based conclusions on serological evidence. However, cell-mediated immunity is more relevant for protection against an intracellular pathogen such as B. pseudomallei. This is the first demonstration that exposure to B. pseudomallei may lead to the formation of specific antibodies and the development of cell-mediated immunity in a healthy individual.

Item ID: 10247
Item Type: Article (Refereed Research - C1)
Keywords: Burkholderia pseudomallei; cell-mediated immunity; intracellular pathogen; melioidosis; tropical infections.
ISSN: 1469-0691
Date Deposited: 23 Apr 2010 01:52
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110801 Medical Bacteriology @ 30%
11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110309 Infectious Diseases @ 30%
11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110704 Cellular Immunology @ 40%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
Citation Count from Web of Science Web of Science 8
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